George Allard-Amyotrophic Lateral Sclerosis-(Canada)

Name: George Allard
Sex: Male
Nationality: Canadian
Age: 61Y
Diagnosis: Amyotrophic Lateral Sclerosis(ALS)
Date of Admission: Sept.29th, 2017
Treatment hospital/period: Wu Medical Center/14 days

Before treatment:
The patient found his left leg was weak 2 years ago. He had left foot drop, it was difficult for him to walk, his right leg and arms were all influenced step by step. He also had muscle atrophy, fasciculation and mild pain in limbs. He went to a local hospital and was diagnosed with ALS. It was difficult for him to stand or walk, he was unable to take care of himself at all. It was also difficult for him to chew, swallow or speak. For now, his four limbs are all weak but he is able to walk with walker for a few steps. It is hard for him to swallow, chew or speak.
His spirit and diet are normal. His urination function is normal, he defecates once in two days, he has lost 18 kgs. 

Admission PE:
Bp: 120/80mmHg, Hr: 80/min, breathing rate: 21/min, body temperature: 36.6 degrees. Nutrition status is normal with normal physical development. There is no injury or bleeding spots of his skin and mucosa, no blausucht, no throat congestion. Chest develop is normal, the respiratory sounds in both lungs were lower than normal and there was no dry or moist rales. The heart beat is powerful with regular cardiac rhythm and with no obvious murmur in the valves. The abdomen was soft and bulging with no masses or tenderness.  The liver and spleen were normal, shifting dullness test is negative. The spinal column is normal and there was no edema in the legs.

Nervous System Examination:
Patient was alert and mental status was good. He had a slur in his speech. The memory, orientation and calculation ability were normal . Both pupils were equal in size and round, diameter of 2.5 mm, react well to light and the eyeballs can move freely. There was no nystagmus. Bilateral forehead wrinkle and nasolabial fold are symmetrical. His tongue is in middle but with tongue muscle atrophy and his tongue could not move freely. Showing the teeth is normal but he could not bulge his cheeks. Chewing ability was weak, he could only take liquid food, the bilateral soft palate could not lift powerfully, the uvula was in middle. The neck was soft and he could turn his neck freely. There is obvious muscle atrophy of all 4 limbs, thenar muscles and hand interosseous muscles. Muscle power of the left arm proximal side was 3+ degrees,  distal side was 4 degrees, right arm muscle power was 4 degrees, the hands grip force was 4 degrees. Left leg muscle power was 3 degrees, right side was 4 degrees. The muscle tone of all 4 limbs was normal. Left arm tendon reflex could not be induced, right arm tendon reflex was normal. Tendon reflex of the legs was active. Bilateral ankle clonus were negative. Bilateral Hoffmann sign were negative. Both sides palm jaw reflex was positive. The Babinski sign of both sides was negative. Finger to nose test was stable and accurate, the fast alternate movement was clumsy, finger opposite movement was normal. The heel-knee-tibia test of both sides was not stable as well. The meningeal irritation sign was negative.

Treatment:
After the admission he received related examinations and was diagnosed with Amyotrophic Lateral Sclerosis. He received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair his damaged nerves, replace dead nerves with new injected stem cells, nourish nerves, regulate his immune system and improve blood circulation. This was done with rehabilitation training.     

Post-treatment:
After 14 days treatment the patient’s breathing function got better, his blood oxygen stayed between 95%～98%, he spoke better and swallowing was easier. His movement endurance increased, muscle power of his left side limbs increased, his arms can lift higher, his left leg when stretched out on the bed can now lift off the bed. His muscle power has increased by 20%.