Larisa Reznichenko- 1. Degenerative Osteoarthropathy 2. Grade 2 Hypertension, Very High Risk 3. Hyperlipidemia- (Israeli)

Patient Name: Larisa Reznichenko
Gender: Female
Age: 75 years old
Nationality: Israeli
Diagnoses: 1. Degenerative Osteoarthropathy 2. Grade 2 Hypertension, Very High Risk 3. Hyperlipidemia

Admission Presentation:
The patient was admitted mainly due to bilateral hip and back pain lasting more than one year. She has long-standing medical histories of hypertension and hyperlipidemia. At present, she took enteric-coated aspirin, valsartan, atorvastatin, bisoprolol fumarate, combined folic acid and iron tablets, vitamin D3, vitamin E, compound vitamin B, glucosamine sulfate and calcium supplements on a regular basis. Amlodipine was added when her blood pressure was poorly controlled, yet she rarely took it due to adverse reactions such as edema, resulting in unstable blood pressure management. She denied other chronic illnesses and drug allergies.

Admission Physical Examination:
Blood pressure: 151/79 mmHg; heart rate: 86 beats per minute; height: 149 cm; weight: 76 kg. Breath sounds were clear in both lungs, with no dry or moist rales audible. Cardiac auscultation revealed strong heart sounds without murmurs. The abdomen was flat and soft, with no hepatosplenomegaly. Mild edema was present in bilateral lower extremities.

Neurological Examination:
The patient was alert with poor mental status. Her speech was clear. Memory, calculation and orientation functions were normal. No cranial nerve abnormalities were identified. The neck was supple; muscle strength of all four limbs was grade 5 with normal muscle tone. Physiological limb reflexes were present, and pathological reflexes were negative. Severe pain was noted in bilateral hips and the back, with more severe discomfort on the left side and marked local tenderness. Superficial and deep sensation remained intact. Coordination tests were basically normal. Meningeal irritation signs were negative. Laboratory tests showed elevated serum uric acid.

Treatment Course:
Mesenchymal stem cells were administered to counter chronic inflammation, resist oxidative stress, repair damaged bones, joints and ligaments, and regulate immunity. Neural stem cells were used to boost neural, endocrine and immune support. Adjuvant CAST therapy was provided to improve internal bodily microenvironment, combined with comprehensive rehabilitation training.

Post-Treatment Outcome:
The patient’s bilateral hip and back pain is significantly relieved, accompanied by improved mental state, greatly enhanced physical stamina, energy and exercise endurance, and complete resolution of edema. Her body weight is dropped by 2 kg within one week. Cardiopulmonary function is improved, and blood pressure is stably controlled (systolic blood pressure 110–130 mmHg, diastolic blood pressure below 80 mmHg). Her heart rate is stabilized at approximately 70 beats per minute. She presents a more youthful physical condition. Serum uric acid levels are returned to normal ranges.