Ms. Lee-Limb-girdle Muscular Dystrophy-(USA)

Name: Ms. Lee
Sex: Female
Nationality: USA
Age: 26
Diagnoses: Limb-girdle Muscular Dystrophy type 2A(LGMD)
Treatment hospital/period: Wu Medical Center/14 days

Before treatment:
25 years ago, when Ms. Lee learned to run, she sometimes fell down, but her walking was normal. Her upper limbs were normal, so her parents didn’t care too much. But when she went to school, her teachers found her always fell down. 13 years ago, she was taken to hospital and diagnosed with Limb-girdle Muscular Dystrophy type 2A, she did rehabilitation training, sometimes take Co-Q10 and novain, but there was no good effect. Her lower limbs were weaker, it was hard for her to stand up or walk. Her upper limbs were weak, she had movement problems. She came to our hospital before, her muscle power and grip were improved that time. She wanted more improvement, so she came to our hospital again.
Her spirit, sleep and diets were good. Her urination and defecation were normal. she put up 8 kgs in 6 months.

Admission PE:
Bp: 104/68mmHg, Hr: 68/min. Temperature: 36.4 degrees. Br: 18/min. Weight 61.5kg, height: 165cm. Her skin and mucous membranes were complete, with no yellow stains or petechia on skin and mucous. The respiration of her was clear, rate of respiration was weaker, there were no dry or moist rales. The rhythm of her heartbeat was abnormal with no obvious murmur in the valves. Her abdomen was soft with no pressing pain. The liver and spleen were normal. She had shoulder girdle muscular atrophy. She had slight winged shoulders, it was hard for her to get up, she had to turn over her body, lied on side, hold up her body with both hands, sit up slowly. Her balance ability was bad in standing position. It was hard for her to walk. She had cross-foot and drop-foot.

Nervous System Examination:
Ms. Lee was alert and her spirit was good. Her memory, calculation ability and orientation were normal. Both pupils were equal in size and round, the diameter was 3 mms, both eyes had sensitive response to light stimuli. Both eyeballs could move freely. The nasolabial fold and forehead wrinkle pattern were symmetrical. The tongue was centered in the oral cavity. She didn’t have teeth deflection, when she did check blowing, there was no leak of gas. She was able to raise her soft palates powerful. The muscle power of turning over her head and shrugging her shoulders was at level 4-. It was hard for her to raise arms, the abductor muscle power was at level 3-. Adductor muscle power was at level 3, the flexor muscle power was at level 3, extensor muscle power of left upper limb was at level 4, right limb was at level 4-. The grip of both hands was at level 5. The muscle power of lower limb was at level 3-. The muscle tension was a little lower. The tendon reflex and abdominal reflexes were abnormal. Bilateral Ms. Lee’s sign was negative. Her deep sensation, superficial sensation and epicritic sensation were normal. She was able to do the finger to nose test, finger to finger test and rapid rotation test. She was not able to do the heel-knee-tibia test. The meningeal irritation sign was negative.

Treatment:
After admission, she was diagnosed with Limb-girdle Muscular Dystrophy type 2A(LGMD). She received 3 neural stem cell injections and 3 mesenchymal stem cell injections to repair her nerves, initiate nerves grow up again, improve her blood circulation, nourish neurons, improve her muscle function and improve her immune system. We also gave her daily physical rehabilitation.

Post-treatment:
After 14 days of treatment, her disease stopped progressing, her heart and breathing function were stable, she felt less heavy in limbs, it was easier for her to raise upper limbs, her grip was improved. She was able to walk longer and stand better.