Pablo Sergio-Optic atrophy-(Argentina)

Patient Name: Pablo Sergio
Gender: Male
Age: 45 years old
Nationality: Argentina
Diagnosis: Optic atrophy

Before Treatment:
The patient was admitted with the primary complaint of "complete blindness in both eyes and no light perception for 35 years," diagnosed with "optic atrophy." At the age of 10, the patient suffered complete blindness due to damage to the "one-way valve of the cerebrospinal fluid shunt," resulting in increased intracranial pressure. He underwent cerebrospinal fluid shunt surgery due to hydrocephalus. He denied any other chronic diseases or infectious disease history and had no allergy history; currently, he was only taking collagen peptides.

Admission Physical Examination:
The patient’s blood pressure was 128/77 mmHg, heart rate was 60 beats per minute, and respiratory rate was 20 breaths per minute. He was 164 cm tall and weighs 75 kg. His development was normal, and he was well-nourished. There were no petechiae or jaundice on his skin. His chest was symmetric, with clear breath sounds in both lungs, and no significant dry or wet rales are heard. His heart sounds were strong, with a regular rhythm, and no significant murmurs were noted in the valve areas. His abdomen was soft, and the liver and spleen were not palpable.

Neurological Examination:
The patient was alert and spoke fluently. His calculation ability, memory, and orientation were basically normal. Both pupils were 4.0 mm, with both direct and consensual light reflexes absent. Eye movements in all directions were clumsy, with no significant nystagmus observed. He had no vision and no light perception. Intraocular pressure was not elevated. His forehead wrinkles were symmetric, and his tongue was midline. Neck turning and shoulder shrugging were strong, with normal muscle strength and tone in the limbs. Abdominal reflexes were normal, and deep tendon reflexes in the limbs were also normal. Pathological signs were negative. Superficial and deep sensations were present, and coordination was normal.

Treatment Process:
The patient was diagnosed with "optic atrophy" upon admission. During the hospital stay, he received CAST treatment and a combination of neural stem cells and mesenchymal stem cells to repair the optic nerve lesions, reconstruct optic nerve conduction, nourish the optic nerve and retina, improve the internal environment, modulate the immune system, and provide comprehensive rehabilitation training.

After Treatment:
The patient’s visual function has significantly improved: he exhibits clear direct and consensual light reflexes in both eyes, with an increased speed of pupil response. He has light perception in both eyes and can locate the light source when illuminated with a penlight in both bright and dark environments. He has developed basic object recognition abilities and can see the outline of objects at close range, as well as perceive the difference between light and his palm (and other objects). His eye movements are more flexible compared to his condition upon admission.